Endocrine Abstracts

Context: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. It is important to identify patients in whom surgical cure is not attainable at an early stage, both to inform patients on expected treatment outcome and to select those who are more likely to need additional therapy.Objective: To identify predictors for remission and relapse after TSS in acromegaly.Design: Retrospective study in three large te...

Introduction: The morbidity of craniopharyngioma (CP) includes cognitive dysfunction with attention deficits, impaired episodic memory and processing speed (Fjalldal et al., 2013) and CP patients with hypothalamic damage are more affected. fMRI is a technique used to investigate cortical activity by detecting alterations in blood flow in response to stimuli or actions. Previously pre- and post-meal fMRI responses to visual food cues were investigated showing higher ac...

Objectives: Quality of life (QoL) is severely affected in Graves’ disease (GD) but long-term longitudinal assessment of QoL is lacking. Furthermore, whether QoL is comparable to controls after treatment of GD is unclear. For the first time, we present serial, longitudinal data on thyroid-related QoL during 24 months of follow-up in a cohort of newly diagnosed GD patients. In addition, we compare QoL in GD and controls.Methods: All patients were tre...

Introduction and objective: CD36 is a scavenger receptor that facilitates the membrane transport of long chain fatty acids into muscle and adipose tissue. Polymorphisms in this gene have been related to abnormal serum fatty acids and obesity-related phenotypes with inconsistent results. Gene-diet interactions could modulate these associations. Our aim was to study whether a common functional variant (rs1761667) in this gene will associate with anthropometric variables and plas...

Introduction: In end-stage renal disease (ESRD), thyroid function tests are often abnormal, and their interpretation is not always straightforward. While haemodialysis (HD) procedure has well-established profound effects on the serum levels of a variety of molecules no such data have been published on thyroid hormones.Methods: In 110 ESRD patients, total and free thyroxine (T4 and fT4), total and free triiodothyronine (T3...

Case of 33 years old male patient with an unremarkable past medical history, who after a car accident, a cystic nodular right neck mass was incidentally found by MRI of cervical spine. Physical examination revealed a mildly tender right neck mass. He was clinically and biochemically euthyroid. Denied history of neck irradiation. No family history of thyroid disease or thyroid cancer. Excisional biopsy of right neck mass showed metastasic well differentiated papillary carcinoma...

Background: Adrenal masses can be detected by ultrasound with high sensitivity and specificity. However, a differentiation between benign and malignant adrenal masses is not possible with conventional ultrasound. Contrast-enhanced ultrasound (CEUS) is a established method for the characterization of focal liver lesions. A first pilot study (n=35) analyzing the dynamics of contrast-enhancement during CEUS reported a high sensitivity for differentiation of benign and mali...

Introduction: Vitamin D deficiency is very common in the population, including pregnant women. There are few studies in Spain to explain their causes, so we started one in the city of Burgos, Spain (latitude 42.2° N) in April 2009 to study vitamin D status, factors that can influence and their relationship with gestational diabetes. We present preliminary data from the study on vitamin D levels.Aims: Study in pregnancy: i) vitamin levels, and ii) it...

The diabetic epidemic is increasing worldwide. The suppressor of cytokine signaling 3 (SOCS3) provides a link between cytokine action and their negative consequences on insulin signaling. This potential influence on the development of T2DM makes the gene a potential candidate gene for type 2 diabetes.We investigated the one haplotype tagging single nucleotide polymorphism (htSNP) rs4969168 to examine the impact on T2DM in two independent study population...

It is well known that hypercortisolism is associated with increased morbidity and mortality caused predominantly by vascular and atherosclerotic complications. The effect of hypercortisolism on microvasculature is less known. The aim of this study was to evaluate skin microvascular reactivity (MVR) in relation to arterial hypertension, diabetes mellitus and other possible influencing factors (fibrinolysis, oxidative stress and endothelial function) in patients with Cushing&#14...